Endocrine Abstracts

Objective: Vitamin D deficiency has been shown to alter insulin synthesis and secretion in both humans and animal models. However, less is known on the association between vitamin D and type 2 diabetes mellitus. In the current study we aimed to analyze the relationship between vitamin D levels with glycemic control in type 2 diabetic patients.Material and methods: Three hundred and twenty diabetic patients who are follow up at least 6 months for diabetes...

Objective: The prevalence and incidence of diabetes mellitus (DM) are increasing at all ages, including older populations. Several studies have shown that elderly diabetics have impaired cognitive function compared to age-matched non-diabetics, as well as a higher risk of dementia. In the current study we aimed to analyze relationship between microalbuminuria and cognitive dysfunction in elderly patients with type 2 diabetes.Material and Methods: One hun...

Excessive expression of CyD1 in CCND1 gene increase G1-S phase transition and cellular proliferation. In various tumor types and of the few studies of pituitary adenomas, over expression of CyD1 or amplification in the locus of CCND1 gene, have been demonstrated. In this study, we aimed to investigate the effect of cyclin D1 gene polymorphism on tumor formation in prolactinoma patients.A hundred and thirteen patients and 108 age and gender matched contro...

In prolactinomas, today first choice of treatment is medical treatment with dopamine agonists. Cavernous sinus invasion is not uncommon in prolactinomas and stands out as a blocking factor for surgical removal of the tumor fully. In our study, the presence of cavernous sinus invasion was to investigate the effect on the results of surgical and medical treatment in prolactinomas.Eighty-seven patients followed up with a diagnosis of prolactinoma were inclu...

Prolactinomas are more common tumors by 60% among the hypophysis adenomas. These are often benign, but may present differences in terms of tumor size and treatment responses. Aim of this study was investigate the relationship of serum prolactin levels with tumor size and invasiveness in the prolactinomas.113 patients with the diagnosis of prolactinoma were included to study. Pretreatment plasma levels of prolactin in the time of diagnosis and sella MR im...

Introduction: Prolactinomas, although considered benign, show various intensity of aggressiveness. Some remain constant for whole life period while some harbour initially with invasive extension to the parasellar area. We aimed to evaluate the effect of age and gender on the invasiveness of prolactinomas.Material-methods: One hundred and thirteen patients with prolactinoma were retrospectively evaluated. Magnetic resonance images were carefully examined ...

Introduction: Fine-needle aspiration (FNA) biopsy of thyroid nodules is minimally invasive and safe. The clinical importance of the thyroid nodule evaluation is primarily related to the need to exclude thyroid cancer. We aimed to investigate the relationship between preoperative FNA cytology and results of thyroidectomy in this study.Materials and Methods: Histopathologic examination reports of 302 patients undergoing thyroidectomy and preoperative FNA c...

Cycline D1 gene that plays a crucial role in a cell cycle, have been shown to be expressed more in nonfunctioning pituitary adenomas and functioning invasive pituitary adenomas compared to normal hypophisis tissue and noninvasive pituitary adenomas. A/G polymorphism in CyD1 gene exon 4/intron 4 regions have been demonstrated to affect clinical outcomes and survey in some tumors. Objective of this study was to investigate the effect of polymorphism of cycline D1 gene on the tum...

Majority of prolactinomas consists of the small microadenomas that can be treated with dopamine agonists, but they can present different biological behavior features and not infrequently seen as macroadenomas or in giant adenoma size. There are different results on finding of studies which investigate the relationship between high levels of cell proliferation indicators with tumor behavior in pituitary adenomas. In this study, Ki 67 index to investigate the relationship betwee...

Introduction: Women with polycystic ovary syndrome (PCOS) have an increased prevalence of insulin resistance and related disorders. Endothelial dysfunction and chronic inflammation are early findings in the atherosclerotic process. Elevated serum levels of uric acid may reflect low-grade chronic inflammation. But there are controversial data whether increased the uric acid level in PCOS patients. This study was aimed to examine the relationship between uric acid, lipoprotein l...